Potential Risk of Birth Defects after Acitretin Discontinuation

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Potential risk of birth defects after acitretin discontinuation.

Acitretin (Soriatane®, Neotigason®) is a synthetic retinoid for the treatment of severe forms of psoriasis and disorders of keratinisation. Like other retinoids, acitretin has a teratogenic potential since it affects cellular differentiation and proliferation. With the use of oral isotretinoin (Accutane®, Roaccutane®), malformations involving the central nervous system as well as craniofacial, ...

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Maternal obesity and risk for birth defects.

OBJECTIVE Several studies have shown an increased risk for neural tube defects associated with prepregnancy maternal obesity. Because few recent studies have examined the relation between maternal prepregnancy obesity and overweight and other birth defects, we explored the relation for several birth defects and compared our findings with those of previous studies. METHODS We conducted a popul...

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ژورنال

عنوان ژورنال: Dermatology

سال: 1999

ISSN: 1018-8665,1421-9832

DOI: 10.1159/000018055